Publications

Publications prior to U of T BME

2022


FORMULATION EXCIPIENTS AND THEIR ROLE IN INSULIN STABILITY AND ASSOCIATION STATE IN FORMULATION

Maikawa, C.L.; Nguyen, L.T.; Mann, J.L.; Appel, E.A.* Pharmaceutical Research (2022) PDF

COMBINATORIAL POLYACRYLAMIDE HYDROGELS FOR PREVENTING BIOFOULING ON IMPLANTABLE BIOSENSORS

Chan, D.^; Chien, J.-C.^; Axpe, E.; Blankemeier, L.; Baker, S.W.; Swaminathan, S.; Piunova, V.A.; Zubarev, D.Y.; Maikawa, C.L.; Grosskopf, A.K.; Mann, J.L.; Soh, H.T.*; Appel, E.A.* Advanced Materials (2022) PDF

DELIVERY OF CAR-T CELLS IN A TRANSIENT INJECTABLE STIMULATORY NICHE IMPROVES TREATMENT OF SOLID TUMORS

Grosskopf, A.K.^; Labanieh, L.^; Klysz, D.D.; Roth, G.A.; Xu, P.; Adebowale, O.; Gale, E.C.; Jons, C.K.; Klich, J.H.; Yan, J.; Maikawa, C.L.; Correa, S.; Ou, B.S.; d’Aquino, A.I.; Cochran, J.R.; Chaudhuri, O.; Mackall, C.L.*; Appel, E.A.* Science Advances (2022) PDF

INJECTABLE NANOPARTICLE-BASED HYDROGELS ENABLE THE SAFE AND EFFECTIVE DEPLOYMENT OF IMMUNOSTIMULATORY CD40 AGONIST ANTIBODIES

Correa, S.; Meany, E.L.; Gale, E.C.; Klich, J.H.; Saouaf, O.M.; Mayer, A.T.; Xian, Z.; Liong, C.; Brown, R.A.; Maikawa, C.L.; Grosskopf, A.K.; Mann, J.L.; Idoyaga, J.; Appel, E.A.* Advanced Science (2022) PDF

2021

ULTRA-FAST INSULIN-PRAMLINTIDE CO-FORMULATION FOR IMPROVED GLUCOSE MANAGEMENT IN DIABETIC RATS

Maikawa, C.L.; Chen, P.C.; Vuong, E.T.; Nguyen, L.T.; Mann, J.L.; d’Aquino, A.I.; Lal, R.A.; Maahs, D.M.; Buckingham, B.A.; Appel, E.A.* Advanced Science (2021) PDF

ENGINEERING BIOPHARMACEUTICAL FORMULATIONS TO IMPROVE DIABETES MANAGEMENT

Maikawa, C.L.; d’Aquino, A.I.; Lal, R.A.; Buckingham, B.A.; Appel, E.A.* Science Translational Medicine (2021) PDF

AFFINITY-DIRECTED DYNAMICS OF HOST-GUEST MOTIFS FOR PHARMACOKINETIC MODULATION VIA SUPRAMOLECULAR PEGYLATION

Maikawa, C.L.; d’Aquino, A.I.; Vuong, E.T.; Su, B.; Zou, L.; Chen, P.C.; Nguyen, L.T.; Autzen, A.A.A.; Mann, J.L.; Webber, M.J.*; Appel, E.A.* Biomacromolecules PDF

ENGINEERING INSULIN COLD CHAIN RESILIENCE TO IMPROVE GLOBAL ACCESS

Maikawa, C.L.^; Mann, J.L.^; Kannan, A.; Meis, C.M.; Ou, B.S.; Smith, A.A.A.; Fuller, G.G.; Maahs, D.M.; Appel, E.A.* Biomacromolecules PDF

FULL CLOSED-LOOP OPEN-SOURCE ALGORITHM PERFORMANCE COMPARISON IN PIGS WITH DIABETES

Lal, R.A.^; Maikawa, C.L.^; Lewis, D.; Baker, S.W.; Smith, A.A.A.; Roth, G.A.; Gale, E.C.; Stapleton, L.M.; Mann, J.L.; Yu, A.C.; Correa, S.; Grosskopf, A.K.; Liong, C.S.; Meis, C.M.; Chan, D.; Garner, J.P.; Maahs, D.M.; Buckingham, B.A.; Appel, E.A.* Clinical & Translational Medicine (2021) PDF

CONTROLLING PROPERTIES OF THERMOGELS BY TUNING CRITICAL SOLUTION BEHAVIOUR OF TERNARY COPOLYMERS

Smith, A.A.A.; Maikawa, C.L.; Lopez Hernandez, H.; Appel, E.A.* Polymer Chemistry (2021) PDF

CONSISTENT TUMORIGENESIS WITH SELF-ASSEMBLED HYDROGELS ENABLES HIGH-POWERED MURINE CANCER STUDIES

Grosskopf, A.K.; Correa, S.; Baillet, J.; Maikawa, C.L.; Gale, E.C.; Brown, R.A.; Appel, E.A.* Communications Biology (2021) PDF

ENHANCED HUMORAL IMMUNE RESPONSE BY HIGH DENSITY TLR AGONIST PRESENTATION ON HYPERBRANCHED POLYMERS

Liong, C.S.^; Smith, A.A.A.^; Mann, J.L.; Roth, G.A.; Gale, E.C.; Maikawa, C.L.; Ou, B.S.; Appel, E.A.* Advanced Therapeutics (2021) PDF

SEASONAL IMPACT OF PHOSPHATE-BASED FIRE RETARDANTS ON SOIL CHEMISTRY FOLLOWING PROPHYLACTIC TREATMENT OF VEGETATION

Yu, A.C.; Reinhart, M.; Hunter, R.; Lu, K.; Maikawa, C.L.; Rajakaruna, N.; Acosta, J.D.; Stubler, C.; Appel, C.*; Appel, E.A.* Environmental Science & Technology (2021) PDF

ISTHMIN-1 IS AN ADIPOKINE THAT PROMOTES GLUCOSE UPDATE AND IMPROVES GLUCOSE TOLERANCE AND HEPATIC STEATOSIS

Jiang, Z.; Zhao, M.; Voilquin, L.; Jung, Y.; Aikio, M.A.; Sahai, T.; Dou, F.; Roche, A.; Carcamo-Orive, I.; Knowles, J.W.; Wabitsch, M.; Appel, E.A.; Maikawa, C.L.; Camporez, J.P.; Shulman, G.I.; Tsai, L.; Rosen, E.D.; Gardner, C.D.; Spiegelman, B.M.; Svensson, K.J.* Cell Metabolism (2021) PDF

2020

AN ULTRAFAST INSULIN FORMULATION ENABLED BY HIGH-THROUGHPUT SCREENING OF ENGINEERED POLYMERIC EXCIPIENTS

Mann, J.L.^; Maikawa, C.L.^; Smith, A.A.A.; Grosskopf, A.K.; Baker, S.W.; Roth, G.A.; Meis, C.M.; Gale, E.C.; Liong, C.S.; Correa, S.; Chan, D.; Stapleton, L.S.; Yu, A.C.; Muir, B.; Howard, S.; Postma, A.; Appel, E.A.* Science Translational Medicine (2020) PDF

A CO-FORMULATION OF SUPRAMOLECULARLY STABILIZED INSULIN AND PRAMLINTIDE ENHANCES MEALTIME GLUCAGON SUPPRESSION IN DIABETIC PIGS

Maikawa, C.L.; Smith, A.A.A.; Zou, L.; Roth, G.A.; Gale, E.C.; Stapleton, L.M.; Baker, S.W.; Mann, J.L.; Yu, A.C.; Correa, S.; Grosskopf, A.K.; Liong, C.S.; Meis, C.M.; Chan, D.; Troxell, M.; Maahs, D.M.; Buckingham, B.A.; Webber, M.J.; Appel, E.A.* Nature Biomedical Engineering (2020) PDF

A FLUORESCENCE SANDWICH IMMUNOASSAY FOR THE REAL-TIME CONTINUOUS DETECTION OF GLUCOSE AND INSULIN IN LIVE ANIMALS

Poudineh, M.^; Maikawa, C.L.^; Ma, E.Y.; Pan, J.; Mamerow, D.; Hang, Y.; Baker, S.W.; Beirami, A.; Yoshikawa, A.; Eisenstein, M.; Kim, S.; Vuckovic, J.; Appel, E.A.*; Soh, H.T.* Nature Biomedical Engineering (2020) PDF

SELF-ASSEMBLED, DILUTION-RESPONSIVE HYDROGELS FOR ENHANCED THERMAL STABILITY OF INSULIN BIOPHARMACEUTICALS

Meis, C.M.; Salzman, E.E.; Maikawa, C.L.; Smith, A.A.A.; Mann, J.L.; Grosskopf, A.K.; Appel, E.A.* ACS Biomaterials Science & Engineering (2020) PDF

SITE-SELECTIVE MODIFICATION OF PROTEINS USING CUCURBIT[7]URIL AS SUPRAMOLECULAR PROTECTION FOR N-TERMINAL AROMATIC AMINO ACIDS

Smith, A.A.A.; Maikawa, C.L.; Roth, G.A.; Appel, E.A.* Organic & Biomolecular Chemistry (2020) PDF

NANOPARTICLES PRESENTING POTENT TLR7/8 AGONISTS ENHANCE ANTI-PD-L1 IMMUNOTHERAPY IN CANCER TREATMENT

Smith, A.A.A.^; Gale, E.C.^; Roth, G.A.; Maikawa, C.L.; Correa, S.; Yu, A.C.; Appel, E.A.* Biomacromolecules (2020) PDF

INJECTABLE HYDROGELS FOR SUSTAINED CO-DELIVERY OF SUBUNIT VACCINES ENHANCE HUMORAL IMMUNITY

Roth, G.A.; Gale, E.C.; Alcantara Herandez, M.; Luo, W.; Axpe, E.; Verma, R.; Yin, Q.; Yu, A.C.; Lopez Hernandez, H.; Maikawa, C.L.; Smith, A.A.A.; Davis, M.M.; Pulendran, B.; Idoyaga, I.; Appel, E.A.* ACS Central Science (2020) PDF

2019

STABLE MONOMERIC INSULIN FORMULATIONS ENABLED BY SUPRAMOLECULAR PEGYLATION OF INSULIN ANALOGUES

Maikawa, C.L.^; Smith, A.A.A.^; Zou, L.; Meis, C.M.; Mann, J.L.; Webber, M.J.; Appel, E.A.* Advanced Therapeutics (2019) PDF

BLOCK COPOLYMER COMPOSITION DRIVES FUNCTION OF SELF-ASSEMBLED NANOPARTICLES FOR DELIVERY OF SMALL-MOLECULE CARGO

Maikawa, C.L.; Sevit, A.; Lin, B.; Wallstrom, R.J.; Mann, J.L.; Yu, A.C.; Waymouth, R.M.; Appel, E.A.* Journal of Polymer Science: Polymer Chemistry (2019) PDF

Biointerfacing Materials | Maikawa Lab